解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Transcription factor (TF) GAMYB, belonging to MYB family (named after the gene of the avian myeloblastosis virus) is a master gibberellin (GA)-induced regulatory protein that is crucial for development and germination of cereal grain and involved in anther formation. It activates many genes including high-mo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06991-3
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Rainbow trout is a significant fish farming species under temperate climates. Female reproduction traits play an important role in the economy of breeding companies with the sale of fertilized eggs. The objectives of this study are threefold: to estimate the genetic parameters of female reproduction traits, ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06955-7
更新日期:2020-08-14 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC genomics
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12864-020-06939-7
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Closely related species of the carp family (Cyprinidae) have evolved distinctive abilities to survive under cold stress, but molecular mechanisms underlying the generation of cold resistance remain largely unknown. In this study, we compared transcriptomic profiles of two carp species to identify key factors...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06946-8
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:The eutherian fibroblast growth factors were implicated as key regulators in developmental processes. However, there were major disagreements in descriptions of comprehensive eutherian fibroblast growth factors gene data sets including either 18 or 22 homologues. The present analysis attempted to revise and ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06958-4
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:Protein phosphorylation by kinases plays crucial roles in various biological processes including signal transduction and tumorigenesis, thus a better understanding of protein phosphorylation events in cells is fundamental for studying protein functions and designing drugs to treat diseases caused by the malf...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06895-2
更新日期:2020-08-04 00:00:00
abstract:BACKGROUND:Alcohol dehydrogenases (ADHs) in plants are encoded by a multigene family. ADHs participate in growth, development, and adaptation in many plant species, but the evolution and function of the ADH gene family in sugarcane is still unclear. RESULTS:In the present study, 151 ADH genes from 17 species including...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06929-9
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Aquaporins (AQPs), as members of the major intrinsic protein (MIP) superfamily, facilitated the permeation of water and other solutes and are involved in multiple biological processes. AQP family exists in almost all living organisms and is highly diversified in vertebrates in both classification and functio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06942-y
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Large difference in cerebrum size exist between avian species and populations of the same species and is believed to reflect differences in processing power, i.e. in the speed and efficiency of processing information in this brain region. During domestication chickens developed a larger cerebrum compared to ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06908-0
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:The ascomycete fungus Zymoseptoria tritici (synonyms: Mycosphaerella graminicola, Septoria tritici) is a major pathogen of wheat that causes the economically important foliar disease Septoria tritici blotch. Despite its importance as a pathogen, little is known about the reaction of this fungus to light. To ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06899-y
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:Wild sugarcane Saccharum spontaneum plants vary in ploidy, which complicates the utilization of its germplasm in sugarcane breeding. Investigations on cold tolerance in relation to different ploidies in S. spontaneum may promote the exploitation of its germplasm and accelerate the improvement of sugarcane va...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06917-z
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:Integrons are genomic elements that mediate horizontal gene transfer by inserting and removing genetic material using site-specific recombination. Integrons are commonly found in bacterial genomes, where they maintain a large and diverse set of genes that plays an important role in adaptation and evolution. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06830-5
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Whilst adaptive facultative sex allocation has been widely studied at the phenotypic level across a broad range of organisms, we still know remarkably little about its genetic architecture. Here, we explore the genome-wide basis of sex ratio variation in the parasitoid wasp Nasonia vitripennis, perhaps the b...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06904-4
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Currently, diabetes has become one of the leading causes of death worldwide. Fasting plasma glucose (FPG) levels that are higher than optimal, even if below the diagnostic threshold of diabetes, can also lead to increased morbidity and mortality. Here we intend to study the magnitude of the genetic influence...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06898-z
更新日期:2020-07-18 00:00:00
abstract:BACKGROUND:Fitness epistasis, the interaction effect of genes at different loci on fitness, makes an important contribution to adaptive evolution. Although fitness interaction evidence has been observed in model organisms, it is more difficult to detect and remains poorly understood in human populations as a result of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06874-7
更新日期:2020-07-11 00:00:00
abstract:BACKGROUND:Soybean (Glycine max) is an important oil provider and ecosystem participant. The protein phosphatase 2C (PP2C) plays important roles in key biological processes. Molecular evolution and functional analysis of the PP2C family in soybean are yet to be reported. RESULTS:The present study identified 134 GmPP2C...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06877-4
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Maternal effects contribute to adaptive significance for shaping various phenotypes of many traits. Potential implications of maternal effects are the cause of expression diversity, but these effects on mRNA expression and alternative splicing (AS) have not been fully elucidated in hybrid animals. RESULTS:T...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06866-7
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:The gonad is the major factor affecting animal reproduction. The regulatory mechanism of the expression of protein-coding genes involved in reproduction still remains to be elucidated. Increasing evidence has shown that ncRNAs play key regulatory roles in gene expression in many life processes. The roles of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06826-1
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role in substance and energy metabolism. Predictably, most metabolic proce...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06837-y
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Mitochondrial genomic sequences are known to be variable. Comparative analyses of mitochondrial genomes can reveal the nature and extent of their variation. RESULTS:Draft mitochondrial genomes of 16 Tremella fuciformis isolates (TF01-TF16) were assembled from Illumina and PacBio sequencing data. Mitochondri...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06846-x
更新日期:2020-06-24 00:00:00
abstract:BACKGROUND:Parasites employ proteases to evade host immune systems, feed and replicate and are often the target of anti-parasite strategies to disrupt these interactions. Myxozoans are obligate cnidarian parasites, alternating between invertebrate and fish hosts. Their genes are highly divergent from other metazoans, a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6705-y
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:The plastome of medicinal and endangered species in Kingdom of Saudi Arabia, Barleria prionitis was sequenced. The plastome was compared with that of seven Acanthoideae species in order to describe the plastome, spot the microsatellite, assess the dissimilarities within the sampled plastomes and to infer the...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06798-2
更新日期:2020-06-06 00:00:00
abstract:BACKGROUND:Lipopolysaccharide (LPS) endotoxin stimulates pro-inflammatory pathways and is a key player in the pathological mechanisms involved in the development of endometritis. This study aimed to investigate LPS-induced DNA methylation changes in bovine endometrial epithelial cells (bEECs), which may affect endometr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06777-7
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Most of our understanding on the social behavior and genomics of bees and other social insects is centered on the Western honey bee, Apis mellifera. The genus Apis, however, is a highly derived branch comprising less than a dozen species, four of which genomically characterized. In contrast, for the equally ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06784-8
更新日期:2020-06-03 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC genomics
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12864-020-6754-2
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Use of genomic tools to characterize wildlife populations has increased in recent years. In the past, genetic characterization has been accomplished with more traditional genetic tools (e.g., microsatellites). The explosion of genomic methods and the subsequent creation of large SNP datasets has led to the p...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-06783-9
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Compromised intestinal barrier (CIB) has been associated with many enteropathies, including colorectal cancer (CRC) and inflammatory bowel disease (IBD). We hypothesized that CIB could lead to increased host-derived contents including epithelial cells into the gut, change its physio-metabolic properties, and...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6749-z
更新日期:2020-05-11 00:00:00
abstract:BACKGROUND:Genetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are left with a gap in the map from genotype to phenotype. Several approaches have been used to fill this gap, including those that at...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6739-1
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:Pitayas are currently attracting considerable interest as a tropical fruit with numerous health benefits. However, as a long-day plant, pitaya plants cannot flower in the winter season from November to April in Hainan, China. To harvest pitayas with high economic value in the winter season, it is necessary t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6726-6
更新日期:2020-04-29 00:00:00
abstract:BACKGROUND:Nontuberculous mycobacterium (NTM) species are ubiquitous microorganisms. NTM pulmonary disease (NTM-PD) is thought to be caused not by human-to-human transmission but by independent environmental acquisition. However, recent studies using next-generation sequencing (NGS) have reported trans-continental spre...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6738-2
更新日期:2020-04-23 00:00:00
abstract:BACKGROUND:Yellow-feathered chickens (YFCs) have a long history in China. They are well-known for the nutritional and commercial importance attributable to their yellow color phenotype. Currently, there is a huge paucity in knowledge of the genetic determinants responsible for phenotypic and biochemical properties of t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6736-4
更新日期:2020-04-20 00:00:00
abstract:BACKGROUND:During cancer progression, malignant cells accumulate somatic mutations that can lead to genetic aberrations. In particular, evolutionary events akin to segmental duplications or deletions can alter the copy-number profile (CNP) of a set of genes in a genome. Our aim is to compute the evolutionary distance b...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6611-3
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:The term pan-genome was proposed to denominate collections of genomic sequences jointly analyzed or used as a reference. The constant growth of genomic data intensifies development of data structures and algorithms to investigate pan-genomes efficiently. RESULTS:This work focuses on providing a tool for dis...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6610-4
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Lung aging is characterized by a number of structural alterations including fibrosis, chronic inflammation and the alteration of inflammatory cell composition. Chronic exposure to cigarette smoke (CS) is known to induce similar alterations and may contribute to premature lung aging. Additionally, aging and C...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6712-z
更新日期:2020-04-09 00:00:00
abstract:BACKGROUND:The nucleoli, including their proteomes, of higher eukaryotes have been extensively studied, while few studies about the nucleoli of the lower eukaryotes - protists were reported. Giardia lamblia, a protist with the controversy of whether it is an extreme primitive eukaryote or just a highly evolved parasite...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6679-9
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:The process of alternative splicing provides a unique mechanism by which eukaryotes are able to produce numerous protein products from the same gene. Heightened variability in the proteome has been thought to potentiate increased behavioral complexity and response flexibility to environmental stimuli, thus c...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6600-6
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Sheath blight (SB), caused by Rhizoctonia solani, is a common rice disease worldwide. Currently, rice cultivars with robust resistance to R. solani are still lacking. To provide theoretic basis for molecular breeding of R. solani-resistant rice cultivars, the changes of transcriptome profiles in response to ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6645-6
更新日期:2020-03-19 00:00:00
abstract:BACKGROUND:Mice of the genus Apodemus are one the most common mammals in the Palaearctic region. Despite their broad range and long history of ecological observations, there are no whole-genome data available for Apodemus, hindering our ability to further exploit the genus in evolutionary and ecological genomics contex...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6603-3
更新日期:2020-03-18 00:00:00
abstract:BACKGROUND:The circadian rhythms regulate physiological functions and metabolism. Circadian Time (CT) is a unit to quantify the rhythm of endogenous circadian clock, independent of light influence. To understand the gene expression changes throughout CT, C57BL/6 J mice were maintained under constant darkness (DD) for 6...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6639-4
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:Genomic inversion is one type of structural variations (SVs) and is known to play an important biological role. An established problem in sequence data analysis is calling inversions from high-throughput sequence data. It is more difficult to detect inversions because they are surrounded by duplication or ot...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6585-1
更新日期:2020-03-05 00:00:00